Formaldehyde → 3-(trifluoroacetyl)-1H-indole-1-ylmethanol

HRID 1983052노트

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HRID 1983052 반응식
[F:1][C:2]([F:15])([F:14])[C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)=[O:4].[CH2:16]=[O:17]>C(N(CC)CC)C.CC(C)=O>[F:15][C:2]([F:1])([F:14])[C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]([CH2:16][OH:17])[CH:6]=1)=[O:4]

참가 물질

5

반응물 2

HCID 712FormaldehydeHCID 5891263-(Trifluoroacetyl)indole

생성물 1

HCID 231491933-(trifluoroacetyl)-1H-indole-1-ylmethanol수율 97.9%

시약·촉매·용매 2

HCID 8471Triethylamine촉매HCID 180Acetone용매

반응 조건

온도
130 °C

실험 절차

The mixture of 4.80 g of 3-(trifluoroacetyl)-1H-indole, 1.35 g of paraformaldehyde and 0.10 g of triethylamine was stirred at 130° C. for 2 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered, and then the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, and hexane was added to the residue, as a result, a crystal was formed. The crystal was collected to obtain 5.36 g of 3-(trifluoroacetyl)-1H-indole-1-ylmethanol.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. additionwas added to the residue, as a result
  5. customa crystal was formed
  6. customThe crystal was collected

출처 및 근거

ORD 기록
ord-c0833845bd4d4bfc98159442bc2ddafb
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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