Formaldehyde → HCID 23149182, 화합물

HRID 1983055노트

반응식

HRID 1983055 반응식
[Cl:1][C:2]([Cl:10])([F:9])[S:3][C:4]1[CH:5]=[N:6][NH:7][CH:8]=1.[O:11]1CCC[CH2:12]1.C=O>O.[OH-].C([N+](CCCC)(CCCC)CCCC)CCC>[Cl:1][C:2]([Cl:10])([F:9])[S:3][C:4]1[CH:5]=[N:6][N:7]([CH2:12][OH:11])[CH:8]=1

참가 물질

6

반응물 3

HCID 712FormaldehydeHCID 8028TetrahydrofuranHCID 23149183HCID 23149183, 화합물

생성물 1

HCID 23149182HCID 23149182, 화합물

시약·촉매·용매 2

HCID 962Water용매3회HCID 2723671Tetrabutylammonium Hydroxide용매

실험 절차

0.19 g of 4-{[dichlorofluoromethyl]thio}-1H-pyrazole was dissolved to 5 ml of tetrahydrofuran. 5 ml of formaldehyde 36% in water and 0.1 ml of tetrabutylammonium hydroxide 10% in water were added to the solution, followed by stirring at room temperature for 4 hours. Water was added to the reaction mixture, and extracted with MTBE. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.22 g of 4-{[dichlorofluoromethyl]thio}-1H-pyrazole-1-ylmethanol.

후처리

  1. extractionextracted with MTBE
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-88e67316c6b842e086de44ac8c9843c5
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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