5-Methyl-3-phenylisoxazole-4-carboxylic acid → HCID 67215761, 화합물

HRID 1983186

반응식

HRID 1983186 반응식
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([OH:15])=O.[S:16]1[CH:20]=[CH:19][C:18]([C:21]([NH:23][NH2:24])=O)=[CH:17]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[C:13]1[O:15][C:21]([C:18]2[CH:19]=[CH:20][S:16][CH:17]=2)=[N:23][N:24]=1

참가 물질

3

반응물 2

HCID 143435-Methyl-3-phenylisoxazole-4-carboxylic acidHCID 468648Thiophene-3-carbohydrazide

생성물 1

HCID 67215761HCID 67215761, 화합물수율 38%

실험 절차

As described for example 121, 5-methyl-3-phenylisoxazole-4-carboxylic acid (357 mg, 1.76 mmol) using thiophene-3-carboxylic acid hydrazide instead of thiophene-2-carboxylic acid hydrazide was converted to the title compound (SiO2, heptane:ethyl acetate=90:10 to 60:40, 207 mg, 38%) which was obtained as a yellow semisolid. MS: m/e=310.3 [M+H]+.

출처 및 근거

ORD 기록
ord-68f5e694037b4fa8a3197d93ec079673
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541372B2

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