3-(3-fluorophenyl)-6-nitro-1H-indazole → 3-(3-Fluorophenyl)-1H-6-indazolamine

HRID 1983469노트

반응식

HRID 1983469 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([N+:17]([O-])=O)=[CH:14][CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1>CO.C(OCC)(=O)C.[OH-].[Pd+2].[OH-].[C]>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 1

HCID 222608953-(3-fluorophenyl)-6-nitro-1H-indazole

생성물 1

HCID 222606883-(3-Fluorophenyl)-1H-6-indazolamine수율 53.6%

시약·촉매·용매 3

HCID 178502593HCID 178502593, 화합물촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매2회

실험 절차

To a solution of 300 mg of 3-(3-fluorophenyl)-6-nitro-1H-indazole in 5 ml methanol and 2.5 ml ethyl acetate was added 60 mg of 20% palladium hydroxide-carbon (water content: 50%), and the mixture was subjected to hydrogenation at room temperature at normal pressure for 7.5 hours. After adding 2.5 ml of ethyl acetate to the reaction mixture, the catalyst was filtered off through Celite. The solvent was evaporated, and the crude product was suspended in ethyl acetate-diisopropyl ether, to give 142 mg of the title compound as white crystals.

후처리

  1. filtrationthe catalyst was filtered off through Celite
  2. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-e2bea368a6b94fa4bec68e335ec0eeca
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541376B2

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