Potassium Carbonate → 4-(4-Chlorophenyl)-1-[3-(5,11-dihydro-7-(1-propoxy)carbonyl-[1]benzoxepino[2,3-b]pyridin-5-ylidene)propyl]piperidine-4-ol

온도

55 °C

To a solution of the compound of Example 118 (109 mg, 0.22 mmol) in dry DMF (5 ml) was added potassium carbonate (91 mg) followed by propyl iodide (24 μL, 0.66 mmol). The mixture was heated to 55° C. for 14 hours. The mixture was diluted with ethyl acetate (200 ml), washed twice with water (200 ml) and then with brine (100 ml), and dried with sodium sulfate. The organic solvent was removed under reduced pressure and the residue subjected to silica gel chromatography using a dichloromethane:methanol gradient (0 to 5% MeOH over 1 hour) to give the title compound (103 mg).

1. washwashed twice with water (200 ml)
2. dry with materialwith brine (100 ml), and dried with sodium sulfate
3. customThe organic solvent was removed under reduced pressure

ORD 기록

ord-3386be2a93eb4b93be33d7a08b0a4eb8

출처 데이터셋

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07541365B2