참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Benzenemethanol, alpha-ethenyl-, 1-acetate | HCID 111277 | — |
| 촉매 | 4-Methoxyphenol | HCID 9015 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | alpha-Vinylbenzyl alcohol | HCID 92986 | 95% |
반응 단계
120 grams (0.6876 mol) of vinylbenzyl acetate, inhibited with 10 mg of MEHQ were added to a one liter 3-neck round bottom flask equipped with a condenser, mechanical stirrer and thermometer, followed by 50 grams (1.25 mol) of sodium hydroxide. 50 mL of water and 300 mL of ethanol were then added and the contents of the flask heated at reflux (65° C.) for 2 hours. After the mixture was allowed to cool to room temperature, water was added. The content of the flask was poured into a separatory funnel and extracted with chloroform several times. The chloroform extract was subsequently washed several times with water and dried over magnesium sulfate. Removal of the chloroform on the rotary evaporator afforded 83 grams of the vinylbenzyl alcohol product (95% yield). The purification was accomplished by vacuum distillation.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07544453B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_06 |
|---|
| ORD ID | ord-4c66511c7ff14b63905c91ffc415ca9e |
|---|
| 출처 메모 | uspto-grants-2009_06 |
|---|
