Dimethylamine → HCID 57713885, 화합물

HRID 1984047노트

반응식

HRID 1984047 반응식
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[NH:14][CH3:15])[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].C(OCC)(=O)C.[CH3:22][NH:23][CH3:24]>>[CH3:22][N:23]([CH3:24])[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[NH:14][CH3:15])[C:8]([OH:10])=[O:9])(=[O:4])=[O:3]

참가 물질

4

반응물 3

HCID 674DimethylamineHCID 8857Ethyl AcetateHCID 57713890HCID 57713890, 화합물

생성물 1

HCID 57713885HCID 57713885, 화합물수율 92%

실험 절차

3-(Chlorosulfonyl)-4-(methylamino)benzoic acid (1.2, 0.515 g, 2.06 mmol) was dissolved in ethyl acetate (8 mL, 0.08 mol). Dimethylamine (0.4 mL, 0.008 mol) was added next. The reaction was left to stir for 4 hours. The reaction was extracted with 0.5 M HCl, washed with water and brine, and the organic layer dried over magnesium sulfate. The ethyl acetate was evaporated and the crude product 1.3.Af was obtained in 92% yield. MS analysis (m−1)=257.

후처리

  1. waitThe reaction was left
  2. extractionThe reaction was extracted with 0.5 M HCl
  3. washwashed with water and brine
  4. dry with materialthe organic layer dried over magnesium sulfate
  5. customThe ethyl acetate was evaporated
  6. customwas obtained in 92% yield

출처 및 근거

ORD 기록
ord-594541c22e49437db4f254a9f996dd28
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544676B2

반응 노트

불러오는 중…