Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-(4-Methylpiperazin-1-yl)pent-4-yn-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethyl chloroformate | HCID 10928 | — |
| 반응물 | 4-Pentynoic acid | HCID 22464 | — |
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(4-Methylpiperazin-1-yl)pent-4-yn-1-one | HCID 57713812 | — |
반응 단계
A solution of 4-pentynoic acid (519 mg, 5.29 mmol) and Et3N (737 μL, 5.29 mmol) in DCM (10 mL) was treated with ethyl chloroformate (504 μL, 5.29 mmol) at rt for 15 min. Then N-methyl-piperazine (588 μL, 5.29 mmol) was added, and stirring was prolonged for 45 min. Work-up (sat. aq. NaHCO3) and concentration gave the title compound as a colorless oil. 1H NMR (CDCl3) δ 3.63 (t, 2H), 3.48 (t, 2H), 2.55 (m, 4H), 2.38 (quint., 4H), 2.30 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07544672B2 |
| 출처 데이터셋 | uspto-grants-2009_06 |
| ORD ID | ord-4251d02f6efa41f88dd90cc28264d645 |
| 출처 메모 | uspto-grants-2009_06 |