Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → (5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(morpholino)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | (4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone | HCID 11603838 | — |
| 반응물 | 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid difluoropiperidine hydrochloride salt | HCID 131728197 | — |
| 생성물 | (5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(morpholino)methanone | HCID 11717680 | — |
반응 단계
In analogy to the procedure described for the synthesis of intermediate 1, the title compound was synthesized from 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid difluoropiperidine hydrochloride salt with one equivalent of lithium chloride (intermediate 1, step 3) and morpholine. The title compound was obtained in 60% yield as off-white solid. MS (m/e): 372.5 (MH+, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745479B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-2703a310ed1e4bb19eed67233c4aa533 |
| 출처 메모 | uspto-grants-2010_06 |