Morpholine → (5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(morpholino)methanone

HRID 19841

반응식

HRID 19841 반응식
FC1(F)[CH2:7][CH2:6][N:5]([C:8]([C:10]2[NH:11][C:12]3[C:17]([CH:18]=2)=[CH:16][C:15]([O:19][CH:20]2[CH2:25][CH2:24][N:23]([CH:26]([CH3:28])[CH3:27])[CH2:22][CH2:21]2)=[CH:14][CH:13]=3)=[O:9])[CH2:4][CH2:3]1.Cl.FC1(F)CCNCC1.C(N1CCC([O:48]C2C=C3C(=CC=2)NC(C(O)=O)=C3)CC1)(C)C.N1CCOCC1>>[CH:26]([N:23]1[CH2:24][CH2:25][CH:20]([O:19][C:15]2[CH:16]=[C:17]3[C:12](=[CH:13][CH:14]=2)[NH:11][C:10]([C:8]([N:5]2[CH2:4][CH2:3][O:48][CH2:7][CH2:6]2)=[O:9])=[CH:18]3)[CH2:21][CH2:22]1)([CH3:28])[CH3:27]

참가 물질

4

반응물 3

HCID 8083MorpholineHCID 11603838(4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone3회HCID 1317281975-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid difluoropiperidine hydrochloride salt

생성물 1

HCID 11717680(5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(morpholino)methanone

실험 절차

In analogy to the procedure described for the synthesis of intermediate 1, the title compound was synthesized from 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid difluoropiperidine hydrochloride salt with one equivalent of lithium chloride (intermediate 1, step 3) and morpholine. The title compound was obtained in 60% yield as off-white solid. MS (m/e): 372.5 (MH+, 100%).

출처 및 근거

ORD 기록
ord-2703a310ed1e4bb19eed67233c4aa533
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745479B2

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