Potassium Carbonate → di(tert-butyl) 1-(4-hydroxybutyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-ylimidodicarbonate

HRID 1984404노트

반응식

HRID 1984404 반응식
C(=O)([O-])[O-].[K+].[K+].C([O:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[N:16]([CH2:43][CH2:44][CH3:45])[N:17]=[C:18]2[C:27]=1[C:26]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:20]=[C:19]2[N:28]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])(=O)C>CO>[OH:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[N:16]([CH2:43][CH2:44][CH3:45])[N:17]=[C:18]2[C:27]=1[C:26]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:20]=[C:19]2[N:28]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 669589344-{4-[bis(tert-butoxycarbonyl)amino]-2-propyl-2H-pyrazolo[3,4-c]quinolin-1-yl}butyl acetate

생성물 1

HCID 66958564di(tert-butyl) 1-(4-hydroxybutyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-ylimidodicarbonate수율 18%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Potassium carbonate (6 mg, 0.041 mmol) was added to a solution of 4-{4-[bis(tert-butoxycarbonyl)amino]-2-propyl-2H-pyrazolo[3,4-c]quinolin-1-yl}butyl acetate (0.8823 g, 1.632 mmol) in methanol (5 mL). The mixture was stirred at ambient temperature for 1.3 hours. The volatiles were removed under reduced pressure. The resulting oil was purified by flash chromatography (silica gel, eluted with 100% ethyl acetate) to yield 0.1466 g of di(tert-butyl) 1-(4-hydroxybutyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-ylimidodicarbonate in about 87% purity.

후처리

  1. customThe volatiles were removed under reduced pressure
  2. customThe resulting oil was purified by flash chromatography (silica gel, eluted with 100% ethyl acetate)

출처 및 근거

ORD 기록
ord-1dee8c66edf84489b64d4a2c0e3e9b29
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544697B2

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