Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1984430생성일: 2026년 10월 27일
Sodium Iodide → 2-[4-(4-amino-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)butyl]-1H-isoindole-1,3(2H)-dione
https://huagongshe.com/reaction/1984430
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Phthalimide potassium salt | HCID 24194345 | — |
| 반응물 | 1-(4-chlorobutyl)-2-methyl-2H-pyrazolo[3,4-c]quinolin-4-amine | HCID 57717502 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-[4-(4-amino-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)butyl]-1H-isoindole-1,3(2H)-dione | HCID 66958800 | 70.2% |
반응 단계
Potassium phthalimide (4.90 mg, 26.4 mmol), sodium iodide (495 mg, 3.30 mmol), and DMF (22 mL) were added to 1-(4-chlorobutyl)-2-methyl-2H-pyrazolo[3,4-c]quinolin-4-amine (4.00 g, 13.2 mmol, prepared as described in Parts A-F of Examples 454-489), and the reaction was heated at 90° C. for two hours under a nitrogen atmosphere and allowed to cool to ambient temperature. Water (100 mL) was added and a precipitate formed and was isolated by filtration to yield 3.7 g of 2-[4-(4-amino-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)butyl]-1H-isoindole-1,3 (2H)-dione that was used in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07544697B2 |
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| 출처 데이터셋 | uspto-grants-2009_06 |
|---|
| ORD ID | ord-7d86a14a42d64662a5e9020572f9ba23 |
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| 출처 메모 | uspto-grants-2009_06 |
|---|
