Pyridine → 1-[(4-Nitrophenyl)sulfonyl]piperidine

HRID 1984575

반응식

HRID 1984575 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[N:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.N1CCCCC1>ClCCl>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 74044-Nitrobenzenesulfonyl chlorideHCID 8082Piperidine

생성물 1

HCID 7236241-[(4-Nitrophenyl)sulfonyl]piperidine수율 91%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 4-nitrobenzenesulfonyl chloride 40 g 0.181 mole in dichloromethane 400 ml was added over 30 mins a solution of pyridine 15 g 15.3 ml and piperidine 16.15 g 18.8 ml in dichloromethane 100 ml. The mixture was stirred at room temperature for 2 h and then washed with water, 2M hydrochloric acid and brine, dried MgSO4 and evaporated in vacuo to give 1-(4-nitro-benzenesulfonyl)-piperidine 44.5 g. 1H NMR CDCl3 7.76 (2H, d), 7.40 (2H, d), 3.21 (6H, q), 1.07 (6H, t).

후처리

  1. washwashed with water, 2M hydrochloric acid and brine, dried MgSO4
  2. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-a48dca5e4e0c4dfbaa748365c19e26a4
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544702B2

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