1-Acetylpiperazine → 4-[2-(4-Acetylpiperazin-1-yl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde

HRID 1984627

반응식

HRID 1984627 반응식
C(S([C:5]1[N:6]=[CH:7][C:8]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:12]([C:21]3[CH:28]=[CH:27][C:24]([CH:25]=[O:26])=[CH:23][CH:22]=3)=[N:11][C:9]=2[N:10]=1)=O)C.[C:29]([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)(=[O:31])[CH3:30]>O1CCOCC1>[C:29]([N:32]1[CH2:37][CH2:36][N:35]([C:5]2[N:6]=[CH:7][C:8]3[CH:14]=[C:13]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[C:12]([C:21]4[CH:28]=[CH:27][C:24]([CH:25]=[O:26])=[CH:23][CH:22]=4)=[N:11][C:9]=3[N:10]=2)[CH2:34][CH2:33]1)(=[O:31])[CH3:30]

참가 물질

4

반응물 2

HCID 837951-AcetylpiperazineHCID 577139404-[2-(Ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde

생성물 1

HCID 577139444-[2-(4-Acetylpiperazin-1-yl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
150 °C

실험 절차

To a solution of 4-[2-(ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde (3-1; 63 mg, 0.16 mmole) in dioxane (1 mL) was added 1-acetylpiperazine and heated to 150° C. in a microwave reactor for 30 min. The mixture was concentrated under reduced pressure and the residue was purified by silica gel chromatography (100% Hex. to 100% EtOAc) to give the title compound. LRMS m/z (M+H) Calcd: 438.5, found 438.2.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel chromatography (100% Hex. to 100% EtOAc)

출처 및 근거

ORD 기록
ord-019e8fb0e76c45ddba9887176813719c
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544677B2

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