Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Amino-2-(ethylthio)-5-(hydroxymethyl)pyrimidine → 4-Amino-2-(ethylthio)pyrimidine-5-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Amino-2-(ethylthio)-5-(hydroxymethyl)pyrimidine | HCID 225433 | — |
| 촉매 | Manganese dioxide | HCID 14801 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 4-Amino-2-(ethylthio)pyrimidine-5-carbaldehyde | HCID 59108860 | — |
반응 단계
To a solution of 4-amino-5-hydroxymethyl-2-(ethylthio)pyrimidine (6-1) (9.6 g, 51.89 mmol) in CHCl3 (1 L) was added MnO2 (86.9 g, 415 mmol, 8 equiv). The suspension was stirred at rt overnight. The mixture was filtered through celite and washed with CHCl3. The combined filtrate was concentrated to give the titled compound (6-2). LRMS m/z (M+H) Calcd. 184.1, found 184.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07544677B2 |
| 출처 데이터셋 | uspto-grants-2009_06 |
| ORD ID | ord-087f5877365a4de18c1110f6bbb86239 |
| 출처 메모 | uspto-grants-2009_06 |