참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-(2-(Dimethylamino)ethyl)piperazine | HCID 2736229 | — |
| 반응물 | 4-[2-(Ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde | HCID 57713940 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | HCID 57713955 | HCID 57713955 | — |
반응 단계
To a solution of 4-[2-(ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde (6-4; 900 mg, 2.33 mmoles) in dioxane (1 mL) was added 1-(2-dimethylaminoethyl)-piperazine (66 mg, 2.33 mmoles) and heated to 150° C. in a microwave reactor for 30 min. The mixture was concentrated under reduced pressure and the residue was purified by silica gel chromatography (100% Hex. to 100% EtOAc) to give the title compound. LRMS m/z (M+H) Calcd: 467.2, found 467.6.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07544677B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_06 |
|---|
| ORD ID | ord-2f506c1a8a194f31a3b5d65708e32791 |
|---|
| 출처 메모 | uspto-grants-2009_06 |
|---|
