Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1984637생성일: 2026년 10월 27일
n,n-Dimethylpiperazine-1-carboxamide → 4-[7-(4-formylphenyl)-6-phenylpyrido[2,3-d]pyrimidin-2-yl]-N,N-dimethylpiperazine-1-carboxamide
https://huagongshe.com/reaction/1984637
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | n,n-Dimethylpiperazine-1-carboxamide | HCID 712909 | — |
| 반응물 | 4-[2-(Ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde | HCID 57713940 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-[7-(4-formylphenyl)-6-phenylpyrido[2,3-d]pyrimidin-2-yl]-N,N-dimethylpiperazine-1-carboxamide | HCID 57713959 | — |
반응 단계
To a solution of 4-[2-(ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde (6-4; 100 mg, 0.258 mmole) in dioxane (1 mL) was added N,N-dimethylpiperazine-1-carboxamide (48 mg, 0.309 mmole) and heated to 150° C. in a microwave reactor for 30 min. The mixture was concentrated under reduced pressure and the residue was purified by silica gel chromatography (100% Hex. to 100% EtOAc) to give the title compound. LRMS m/z (M+H) Calcd: 467.2, found 467.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07544677B2 |
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| 출처 데이터셋 | uspto-grants-2009_06 |
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| ORD ID | ord-af3ea743f8a548be9a28127dfcf48c7f |
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| 출처 메모 | uspto-grants-2009_06 |
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