2-Iodophenylacetonitrile → [2-(5-Methyl-3-phenyl-isoxazol-4-ylethynyl)-phenyl]-acetonitrile

HRID 1984653노트

반응식

HRID 1984653 반응식
[C:1]([C:3]1[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:5][O:6][C:7]=1[CH3:8])#[CH:2].I[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH2:22][C:23]#[N:24]>>[CH3:8][C:7]1[O:6][N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:3]=1[C:1]#[C:2][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH2:22][C:23]#[N:24]

참가 물질

3

반응물 2

HCID 44022822-IodophenylacetonitrileHCID 534346474-Ethynyl-5-methyl-3-phenyl-isoxazole

생성물 1

HCID 68853004[2-(5-Methyl-3-phenyl-isoxazol-4-ylethynyl)-phenyl]-acetonitrile수율 87%

실험 절차

As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (110 mg, 0.60 mmol) was converted (using 2-iodo-phenylacetonitrile instead of 2-chloro-4-iodopyridine) to the title compound (SiO2, heptane:ethyl acetate=100:0 to 80:20, 156 mg, 87%) which was obtained as a light brown oil. MS: m/e=375.1 [M+H]+.

출처 및 근거

ORD 기록
ord-761998d8b7414e7a914e36b24a2abae0
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544704B2

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