2-Iodo-1-methyl-1H-imidazole → 5-Methyl-4-(1-methyl-1H-imidazol-2-ylethynyl)-3-phenyl-isoxazole

반응식

[C:1]([C:3]1[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:5][O:6][C:7]=1[CH3:8])#[CH:2].I[C:16]1[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=1>>[CH3:8][C:7]1[O:6][N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:3]=1[C:1]#[C:2][C:16]1[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=1

참가 물질

반응물 2

HCID 3358352-Iodo-1-methyl-1H-imidazole

HCID 534346474-Ethynyl-5-methyl-3-phenyl-isoxazole

생성물 1

HCID 247841825-Methyl-4-(1-methyl-1H-imidazol-2-ylethynyl)-3-phenyl-isoxazole수율 30%

실험 절차

As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (73 mg, 0.40 mmol) was converted (using 2-iodo-1-methyl-1H-imidazole instead of 2-chloro-4-iodopyridine) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 32 mg, 30%) which was obtained as a light brown solid. MS: m/e=264.2 [M+H]+.

출처 및 근거

ORD 기록: ord-465f044ff8504f679b74e16890023e92
출처 데이터셋: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07544704B2

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