4-Bromo-2-isopropylthiazole → HCID 68854104, 화합물

HRID 1984697노트

반응식

HRID 1984697 반응식
[C:1]([C:3]1[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:5][O:6][C:7]=1[CH3:8])#[CH:2].Br[C:16]1[N:17]=[C:18]([CH:21]([CH3:23])[CH3:22])[S:19][CH:20]=1>>[CH:21]([C:18]1[S:19][CH:20]=[C:16]([C:2]#[C:1][C:3]2[C:4]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)=[N:5][O:6][C:7]=2[CH3:8])[N:17]=1)([CH3:23])[CH3:22]

참가 물질

3

반응물 2

HCID 27631824-Bromo-2-isopropylthiazoleHCID 534346474-Ethynyl-5-methyl-3-phenyl-isoxazole

생성물 1

HCID 68854104HCID 68854104, 화합물수율 15%

실험 절차

As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (92 mg, 0.50 mmol) was converted (using 4-bromo-2-isopropylthiazole instead of 2-chloro-4-iodopyridine) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 23 mg, 15%) which was obtained as a yellow oil. MS: m/e=309.3 [M+H]+.

출처 및 근거

ORD 기록
ord-eae507702ae24e6e900ab236926bb86f
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544704B2

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