3-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-ethyl-6-fluoro-1H-indole → 2-Ethyl-6-fluoro-3-piperidin-4-yl-1H-indole

HRID 1984986노트

반응식

HRID 1984986 반응식
C([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([F:23])=[CH:20][CH:21]=3)[NH:16][C:15]=2[CH2:24][CH3:25])[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CO>[CH2:24]([C:15]1[NH:16][C:17]2[C:22]([C:14]=1[CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)[CH3:25]

참가 물질

4

반응물 1

HCID 674537003-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-ethyl-6-fluoro-1H-indole

생성물 1

HCID 577188362-Ethyl-6-fluoro-3-piperidin-4-yl-1H-indole수율 116.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

3-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-ethyl-6-fluoro-1H-indole (1.4 g) is hydrogenated for 1 hour (r.t./1013 mbar) in the presence of 10% Pd/C catalyst (0.3 g) and methanol (25 ml). The catalyst is removed by filtration, the solvent evaporated and the residue washed with small portions of ether. 1.2 g (85%) of pure product is obtained.

후처리

  1. custom(r.t./1013 mbar)
  2. customThe catalyst is removed by filtration
  3. customthe solvent evaporated
  4. washthe residue washed with small portions of ether

출처 및 근거

ORD 기록
ord-35c46ecfe5c842a8b93a7115364dd2db
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544806B2

반응 노트

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