참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Theophylline | HCID 2153 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Diethyl(4-chlorobutyl)phosphonate | HCID 19689195 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Diethyl [4-(1,3-dimethylxanthin-7-yl)butyl]phosphonate | HCID 22446301 | — |
반응 단계
10.9 g (0.05 mol) of 1,3-dimethylxanthine were suspended in 150 ml of DMF, treated with 13.7 g (0.06 mol) of diethyl 4-chlorobutanephosphonate and 7.0 g (0.05 mol) of activated potassium carbonate and heated at 70° C. for approximately 4 hours. The solid was then filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05728686 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-126b62e8f9c14b19bd96ee46b744d0b7 |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
