HCID 57718998, 화합물 → HCID 10195632, 화합물

HRID 1985123노트

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HRID 1985123 반응식
C([O:3][C:4](=[O:37])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH:18]2[CH2:22][N:21]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:26][CH:25]=3)[C:20](=[O:34])[N:19]2[CH3:35])=[CH:11][C:10]=1[CH3:36])([CH3:7])[CH3:6])C>CO>[C:30]([C:27]1[CH:28]=[CH:29][C:24]([CH2:23][N:21]2[CH2:22][CH:18]([CH2:17][CH2:16][CH2:15][C:12]3[CH:13]=[CH:14][C:9]([O:8][C:5]([CH3:6])([CH3:7])[C:4]([OH:37])=[O:3])=[C:10]([CH3:36])[CH:11]=3)[N:19]([CH3:35])[C:20]2=[O:34])=[CH:25][CH:26]=1)([CH3:31])([CH3:32])[CH3:33]

참가 물질

3

반응물 1

HCID 57718998HCID 57718998, 화합물

생성물 1

HCID 10195632HCID 10195632, 화합물수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
0 °C

실험 절차

2-(4-{3-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (0.065 g, 0.128 mmole) is treated with 3:1 MeOH/5.0N NaOH (4 mL) at room temperature overnight, and then concentrated. The resulting residue is diluted with water (2 mL), cooled down to 0° C., acidified to pH=2 by adding concentrated HCl dropwise. The aqueous suspension is loaded on a Chem elut tube and eluted with DCM (50 mL). Evaporation of methylene chloride gives the titled compound as an oil (0.060 g, 98%). Mass [EI+] 481 (M+H)+, [EI−] 479 (M−H)−.

후처리

  1. concentrationconcentrated
  2. additionThe resulting residue is diluted with water (2 mL)
  3. additionby adding concentrated HCl dropwise
  4. washeluted with DCM (50 mL)
  5. customEvaporation of methylene chloride

출처 및 근거

ORD 기록
ord-16bc7c04ce9b40a4821aa1cb8ecb75d0
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544812B2

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