HCID 57719408, 화합물 → HCID 57719830, 화합물

HRID 1985392노트

반응식

HRID 1985392 반응식
[CH3:1][O:2][C:3](=[O:25])[C@@H:4]([O:21][CH:22]([CH3:24])[CH3:23])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][NH:13]C(OC(C)(C)C)=O)[CH:7]=1>O1CCOCC1.Cl>[CH3:1][O:2][C:3](=[O:25])[C@@H:4]([O:21][CH:22]([CH3:23])[CH3:24])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][NH2:13])[CH:7]=1

참가 물질

3

반응물 1

HCID 57719408HCID 57719408, 화합물

생성물 1

HCID 57719830HCID 57719830, 화합물수율 88.3%

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

1.034 g of 3-[3-(t-Butoxycarbonylaminomethyl)phenyl]-2(S)-isopropoxypropionic acid methyl ester was dissolved in 20 ml of hydrogen chloride 1,4-dioxane, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated, the residue was dissolved in ethyl acetate, and washed with saturated aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 653 mg of the title compound as a colorless oil.

후처리

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with saturated aqueous sodium hydrogen carbonate
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-c6fbee78640042efb8b93a3afec12143
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544835B2

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