참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Bromopropanedial | HCID 74945 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | 6-(Carbamothioylamino)pyridine-3-carboxylic acid | HCID 22019093 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-(5-Formyl-thiazol-2-ylamino)-nicotinic acid | HCID 22019054 | 96.3% |
반응 단계
A mixture of 6-thioureido-nicotinic acid (197 mg, 1 mmol), 2-bromomalonaldehyde (166 mg, 1.1 mmol) and sodium acetate (100 mg) in acetic acid (2 mL) was stirred at 100° C. for 20 min. The mixture was then cooled to RT, diluted with water and the precipitates were collected. The solid was washed with water, then methanol and dried in vacuo to afford 6-(5-formyl-thiazol-2-ylamino)-nicotinic acid, (240 mg, 96%). MS m/z 250 (M+H)+. 1H NMR (DMSO-d6) δ 12.7 (s, 1H), 9.12 (s, 1H), 8.92 (s, 1H), 8.38 (s, 1H), 8.24 (d, 1H, J=5.6 Hz), 7.21 (d, 1H, J=5.6 Hz). 13C NMR (DMSO-d6) δ 183.5, 166.0, 165.1, 153.3, 151.5, 148.8, 139.1, 131.2, 120.3, 110.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07547711B2 |
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| 출처 데이터셋 | uspto-grants-2009_06 |
|---|
| ORD ID | ord-2c4b374d3f0f43d587f06df6c0e52c6a |
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| 출처 메모 | uspto-grants-2009_06 |
|---|
