Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-amino-N-cyclopropyl-2,4-difluorobenzamide → 6-{5-[(5-Cyclopropylcarbamoyl-2,4-difluoro-phenylamino)-methyl]-thiazol-2-ylamino}-nicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-amino-N-cyclopropyl-2,4-difluorobenzamide | HCID 21966507 | — |
| 반응물 | 6-(5-Formyl-thiazol-2-ylamino)-nicotinic acid | HCID 22019054 | — |
| 생성물 | 6-{5-[(5-Cyclopropylcarbamoyl-2,4-difluoro-phenylamino)-methyl]-thiazol-2-ylamino}-nicotinic acid | HCID 23544562 | 95% |
반응 단계
6-(5-Formyl-thiazol-2-ylamino)-nicotinic acid (see Example 19) was treated with 5-amino-2,4-difluoro-N-cyclopropylbenzamide in manner similar to the preparation of Example 6 to afford the title compound in 95% yield. LC/MS; (M+H)+=446
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07547711B2 |
| 출처 데이터셋 | uspto-grants-2009_06 |
| ORD ID | ord-be38a8ea2f544ad99a59a26cc4085c5b |
| 출처 메모 | uspto-grants-2009_06 |