2-Azido-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1H-benzimidazole → 2-Amino-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1H-benzimidazole

HRID 1985816노트

반응식

HRID 1985816 반응식
[N:1]([C:4]1[N:8]([C@@H:9]2[O:21][C@H:20]([CH2:22][O:23][C:24](=[O:26])[CH3:25])[C@@H:15]([O:16][C:17](=[O:19])[CH3:18])[C@H:10]2[O:11][C:12](=[O:14])[CH3:13])[C:7]2[CH:27]=[CH:28][CH:29]=[CH:30][C:6]=2[N:5]=1)=[N+]=[N-]>CO.[C].[Pd]>[NH2:1][C:4]1[N:8]([C@@H:9]2[O:21][C@H:20]([CH2:22][O:23][C:24](=[O:26])[CH3:25])[C@@H:15]([O:16][C:17](=[O:19])[CH3:18])[C@H:10]2[O:11][C:12](=[O:14])[CH3:13])[C:7]2[CH:27]=[CH:28][CH:29]=[CH:30][C:6]=2[N:5]=1

참가 물질

4

반응물 1

HCID 866182782-Azido-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1H-benzimidazole

생성물 1

HCID 688410382-Amino-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1H-benzimidazole수율 103.4%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

2-Azido-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-benzimidazole (100 mg) was dissolved in methanol (2 mL). To the solution was added a catalytic amount of 10% palladium-carbon powder, and the mixture was stirred at room temperature under a hydrogen atmosphere for 1 hour. The insoluble material was removed by filtration, and the solvent of filtrate was removed under reduced pressure to give the title compound (97 mg).

후처리

  1. customThe insoluble material was removed by filtration
  2. customthe solvent of filtrate was removed under reduced pressure

출처 및 근거

ORD 기록
ord-73cb82c0a8ce43b08e8ff1e807522535
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07547680B2

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