Morpholine → HCID 11281828, 화합물

HRID 1985865노트

반응식

HRID 1985865 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[CH:11][N:10]([CH2:20][CH2:21][C:22](O)=[O:23])[C:9]2=[S:25])=[CH:4][CH:3]=1.[NH:26]1[CH2:31][CH2:30]O[CH2:28][CH2:27]1>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[CH:11][N:10]([CH2:20][CH2:21][C:22]([N:26]3[CH2:31][CH2:30][CH2:28][CH2:27]3)=[O:23])[C:9]2=[S:25])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 57720839HCID 57720839, 화합물

생성물 1

HCID 11281828HCID 11281828, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-(1-(4-chlorophenyl)-5-(4-fluorophenyl)-1,2-dihydro-2-thioxoimidazol-3-yl)propionic acid (1 eq), 1-3-(dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.7 eq) and morpholine (1.7 eq) in THF is stirred overnight at room temperature. The reaction is quenched with water and extracted with ethyl acetate. The organics are dried and concentrated under vacuum. The residue is purified by chromatography on silica to give 3-(1-(4-chlorophenyl)-5-(4-fluorophenyl)-1,2-dihydro-2-thioxoimidazol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one.

후처리

  1. customThe reaction is quenched with water
  2. extractionextracted with ethyl acetate
  3. customThe organics are dried
  4. concentrationconcentrated under vacuum
  5. customThe residue is purified by chromatography on silica

출처 및 근거

ORD 기록
ord-132844b7891e407897ccd7002242bde6
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07547717B2

반응 노트

불러오는 중…