Cesium carbonate → 1-[3-(benzyloxy)benzyl]-2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole

HRID 1985881

반응식

HRID 1985881 반응식
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C@@H:9]([C:11]1[NH:12][CH:13]=[CH:14][N:15]=1)[CH3:10].C(=O)([O-])[O-].[Cs+].[Cs+].[CH2:22]([O:29][C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([CH2:36]Br)[CH:31]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>CN1CCCC1=O>[CH2:22]([O:29][C:30]1[CH:31]=[C:32]([CH:33]=[CH:34][CH:35]=1)[CH2:36][N:15]1[CH:14]=[CH:13][N:12]=[C:11]1[C@H:9]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([CH3:8])[C:2]=1[CH3:1])[CH3:10])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 15020473-Benzyloxybenzyl bromideHCID 24738933Demiditraz

생성물 1

HCID 577184161-[3-(benzyloxy)benzyl]-2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

To a mixture of the compound of Example 58 (90 mg, 0.45 mmol) and caesium carbonate (244 mg, 0.75 mmol) in 1-methyl-2-pyrrolidinone (1 ml) was added 1-(benzyloxy)-3-(bromomethyl)benzene (139 mg, 0.50 mmol). The reaction mixture was stirred at room temperature for 48 h and then filtered through a Whatman PTFE filter tube (5 μm).

후처리

  1. filtrationfiltered through a Whatman PTFE
  2. filtrationfilter tube (5 μm)

출처 및 근거

ORD 기록
ord-5cda0f4718414c0891c4fdd974eed592
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07547718B2

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