1-(3-Aminopropyl)-4-methylpiperazine → 2-{5-Chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-6-carbonitrile

반응식

C(OC(=O)[NH:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH:23][CH2:24][CH2:25][CH2:26][N:27]4[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]4)[N:18]=3)[S:14][C:13]=2[CH:34]=1)(C)(C)C.[Cl:36]C1N=C(C2SC3C=C(C#N)C=CC=3C=2)C(Cl)=CN=1.NCCCN1CCN(C)CC1>>[Cl:36][C:22]1[C:17]([C:15]2[S:14][C:13]3[CH:34]=[C:9]([C:8]#[N:7])[CH:10]=[CH:11][C:12]=3[CH:16]=2)=[N:18][C:19]([NH:23][CH2:24][CH2:25][CH2:26][N:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)=[N:20][CH:21]=1

참가 물질

반응물 3

HCID 783281-(3-Aminopropyl)-4-methylpiperazine

HCID 68859103(2-{2-[3-(4-Methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophen-6-ylmethyl)-carbamic acid tert-butyl ester

HCID 866253492-(2,5-Dichloropyrimidin-4-yl)benzo[b]thiophene-6-carbonitrile

생성물 1

HCID 688561992-{5-Chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-6-carbonitrile

실험 절차

Using the method of (2-{2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophen-6-ylmethyl)-carbamic acid tert-butyl ester, the title compound is synthesized from 2-(2,5-dichloropyrimidin-4-yl)benzo[b]thiophene-6-carbonitrile and 1-(3-aminopropyl)-4-methylpiperazine and isolated as a solid. ES+(m/z) 427 (35Cl) and 429 (37Cl) [M+H].