1-(3-Aminopropyl)-4-methylpiperazine → [5-Chloro-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methyl-piperazin-1-yl)-propyl]-amine

HRID 1986240노트

반응식

HRID 1986240 반응식
Cl.Cl.Cl.S1C(C2C=CN=C([NH:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)N=2)=CC2C=CC=CC1=2.Cl[C:31]1[N:36]=[C:35]([C:37]2[S:41][C:40]3[C:42]([O:46][CH3:47])=[CH:43][CH:44]=[CH:45][C:39]=3[CH:38]=2)[C:34]([Cl:48])=[CH:33][N:32]=1.NCCCN1CCN(C)CC1>>[Cl:48][C:34]1[C:35]([C:37]2[S:41][C:40]3[C:42]([O:46][CH3:47])=[CH:43][CH:44]=[CH:45][C:39]=3[CH:38]=2)=[N:36][C:31]([NH:15][CH2:16][CH2:17][CH2:18][N:19]2[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]2)=[N:32][CH:33]=1

참가 물질

4

반응물 3

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 68855962[4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochlorideHCID 866253692,5-Dichloro-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidine

생성물 1

HCID 68857035[5-Chloro-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methyl-piperazin-1-yl)-propyl]-amine

실험 절차

Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is prepared from 2,5-dichloro-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidine and 1-(3-aminopropyl)-4-methylpiperazine and isolated as a yellowish solid. ES+(m/z) 432(35Cl) and 434(37Cl) [M+H].

후처리

  1. customisolated as a yellowish solid

출처 및 근거

ORD 기록
ord-e5d30b38bc48464db4d04380ac71369c
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07547691B2

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