1-(3-Aminopropyl)-4-methylpiperazine → [5-Bromo-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride

HRID 1986241

반응식

HRID 1986241 반응식
[ClH:1].Cl.Cl.S1C(C2C=CN=C([NH:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)N=2)=CC2C=CC=CC1=2.[Br:30][C:31]1[C:32]([C:38]2[S:42][C:41]3[C:43]([O:47][CH3:48])=[CH:44][CH:45]=[CH:46][C:40]=3[CH:39]=2)=[N:33][C:34]([Cl:37])=[N:35][CH:36]=1.NCCCN1CCN(C)CC1>>[ClH:37].[ClH:1].[ClH:37].[Br:30][C:31]1[C:32]([C:38]2[S:42][C:41]3[C:43]([O:47][CH3:48])=[CH:44][CH:45]=[CH:46][C:40]=3[CH:39]=2)=[N:33][C:34]([NH:15][CH2:16][CH2:17][CH2:18][N:19]2[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]2)=[N:35][CH:36]=1

참가 물질

4

반응물 3

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 68855962[4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochlorideHCID 86625370HCID 86625370, 화합물

생성물 1

HCID 68856938[5-Bromo-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride

실험 절차

Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is prepared from 5-bromo-2-chloro-4-(7-methoxy-benzo[b]thiophen-2-yl)-pyrimidine and 1-(3-aminopropyl)-4-methylpiperazine and isolated as a yellow solid. ES+(m/z) 476 (79Br) and 478 (81Cl) [M+H].

후처리

  1. customisolated as a yellow solid

출처 및 근거

ORD 기록
ord-93cbef253ef146b4938fec8ce1447d5e
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07547691B2

연결된 노트

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