(R)-4-(2-aminoethyl)-3-methylpiperazine-1-carboxylic acid tert-butyl ester → (R)-2-{5-Methyl-2-[2-(2-methylpiperazin-1-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide

반응식

[CH:1]1([NH:4][C:5]([C:7]2[C:15]3[CH:14]=[C:13]([C:16]4[C:21](Cl)=[CH:20][N:19]=[C:18]([NH:23][CH2:24][CH2:25][N:26]5[CH2:31][CH2:30][NH:29][CH2:28][C@H:27]5[CH3:32])[N:17]=4)[S:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)=[O:6])[CH2:3][CH2:2]1.[CH:33]1(NC(C2C3C=C(C4C(C)=CN=C(Cl)N=4)SC=3C=CC=2)=O)CC1.C(OC(N1CCN(CCN)[C@H](C)C1)=O)(C)(C)C>>[CH:1]1([NH:4][C:5]([C:7]2[C:15]3[CH:14]=[C:13]([C:16]4[C:21]([CH3:33])=[CH:20][N:19]=[C:18]([NH:23][CH2:24][CH2:25][N:26]5[CH2:31][CH2:30][NH:29][CH2:28][C@H:27]5[CH3:32])[N:17]=4)[S:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)=[O:6])[CH2:3][CH2:2]1