Chloroacetyl chloride → 6-bromo-8-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one

HRID 1986671노트

반응식

[NH2:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([F:9])[C:3]=1[OH:10].Cl[CH2:12][C:13](Cl)=[O:14].C([O-])([O-])=O.[K+].[K+]>>[Br:8][C:6]1[CH:5]=[C:4]([F:9])[C:3]2[O:10][CH2:12][C:13](=[O:14])[NH:1][C:2]=2[CH:7]=1

참가 물질

반응물 3

HCID 6577Chloroacetyl chloride

HCID 11430Potassium Carbonate

HCID 27376372-Amino-4-bromo-6-fluorophenol

생성물 1

HCID 468564636-bromo-8-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one수율 97.3%

실험 절차

2-Amino-4-bromo-6-flourophenol (95MF2084) (0.078 g, 0.38 mmol), 2-chloroacetyl chloride (0.048 g, 0.42 mmol) and K2CO3 (0.11 g, 0.79 mmol) were mixed according to GP1 to give the title compound as a crude (95MF44) (0.091 g)

출처 및 근거

ORD 기록: ord-3797df04b2b34a6b88a0094464a8ecd0
출처 데이터셋: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07550459B2

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