1,5-bis(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinolinone → HCID 57722990, 화합물

HRID 1987029노트

반응식

HRID 1987029 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:17]2[C:12](=[C:13]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH2:11][CH2:10][C:9]1=[O:27]>ClC1C=CC=CC=1.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:17]2[C:12](=[C:13]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH:11]=[CH:10][C:9]1=[O:27]

참가 물질

4

반응물 1

HCID 577229821,5-bis(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinolinone

생성물 1

HCID 57722990HCID 57722990, 화합물수율 97%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 7964Chlorobenzene용매

실험 절차

1,5-bis(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinolinone (0.85 g, 2.134 mmol) and manganese dioxide (5 g) were heated in chlorobenzene (50 ml) under reflux for 17 h. After cooling, the chlorobenzene was removed in vacuo, ethyl acetate (80 ml) added to the residue, then filtered through celite. The filtrate was evaporated in vacuo to afford the title compound as a yellow solid (0.82 g, 97%)

후처리

  1. temperatureunder reflux for 17 h
  2. temperatureAfter cooling
  3. customthe chlorobenzene was removed in vacuo, ethyl acetate (80 ml)
  4. additionadded to the residue
  5. filtrationfiltered through celite
  6. customThe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-bb2e8340f4bb4307a8995fc99d2d3f8c
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07550480B2

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