Pyridine → N-(4-fluoro-3-nitrophenyl)ethanesulfonamide

HRID 1987223

반응식

HRID 1987223 반응식
[CH2:1]([S:3](Cl)(=[O:5])=[O:4])[CH3:2].[F:7][C:8]1[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16].N1C=CC=CC=1>CCOC(C)=O>[F:7][C:8]1[CH:14]=[CH:13][C:11]([NH:12][S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 11667Ethanesulfonyl chlorideHCID 677684-Fluoro-3-nitroaniline

생성물 1

HCID 3286362N-(4-fluoro-3-nitrophenyl)ethanesulfonamide수율 98.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

EtSO2Cl (21.5 mL, 0.22 mol) was added drop wise to a mixture of 4-fluoro-3-nitroaniline (29.6 g, 0.19 mol) and pyridine (100 mL) at 0° C. The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was diluted with EtOAc (1 L). The resulting solution was washed with HCl 2N (4×200 mL), NaHCO3 saturated solution (4×200 mL) and water (4×200 mL). The organic phase was dried over anhydrous Na2SO4 and the solvent was removed to provide the title product as beige solid (46.3 g)

후처리

  1. washThe resulting solution was washed with HCl 2N (4×200 mL), NaHCO3 saturated solution (4×200 mL) and water (4×200 mL)
  2. dry with materialThe organic phase was dried over anhydrous Na2SO4
  3. customthe solvent was removed

출처 및 근거

ORD 기록
ord-8f16dd7439374421867574e32deead18
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07550495B2

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