Allylamine → N-(3-phenylallyl)-allylamine

HRID 1987232

반응식

HRID 1987232 반응식
[CH2:1](Br)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:11]([NH2:14])[CH:12]=[CH2:13]>O1CCCC1>[C:4]1([CH:3]=[CH:2][CH2:1][NH:14][CH2:11][CH:12]=[CH2:13])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 7853AllylamineHCID 98116Bromomethylstyrene

생성물 1

HCID 4717907N-(3-phenylallyl)-allylamine수율 82%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of cinnamyl bromide (10 g, 50.7 mmol) in 250 mL tetrahydrofuran was added dropwise to a solution of allyl amine (38 ml, 507 mmol) in 50 mL tetrahydrofuran at 0° C. the mixture was allowed to slowly come to room temperature then stirred 20 hours. The tetrahydrofuran was removed in-vacuo, and the residue was partitioned between 500 mL of ethyl acetate and 200 ml of water. The layers were separated, the organic phase was washed with water followed by brine, then dried over sodium sulfate and concentrated to an amber oil. The oil was purified by flash chromatography on an 8×15 cm silica column, eluting with 5% methanol/chloroform followed by 10% methanol/chloroform. Obtained 7.2 g of an amber oil as product. Yield=81%. NMR (300 MHz, CDCl3) δ 7.39-7.20 (m, 5H), 6.54 (d, 1H, J=16 Hz), 6.35-6.26 (m, 1H), 6.01-5.87 (m, 1H), 5.24-5.14 (m, 2H), 3.43 (d, 2H, J=7 Hz), 3.31 (d, 2H, J=6 Hz).

후처리

  1. customto slowly come to room temperature
  2. customThe tetrahydrofuran was removed in-vacuo
  3. customthe residue was partitioned between 500 mL of ethyl acetate and 200 ml of water
  4. customThe layers were separated
  5. washthe organic phase was washed with water
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated to an amber oil
  8. customThe oil was purified by flash chromatography on an 8×15 cm silica column
  9. washeluting with 5% methanol/chloroform

출처 및 근거

ORD 기록
ord-0edf7b13b17c4dbfb2a5d8990978b160
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07550500B2

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