Dichloromethane → 2'-Mercaptobiphenyl-3-ol
반응식
COC1C=C(OC)C=C(OC)C=1C[S:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([OH:19])[CH:14]=1.C(O)(C(F)(F)F)=O.C([SiH](CC)CC)C.C(Cl)Cl>O>[SH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([OH:19])[CH:14]=1참가 물질
6
실험 절차
2′-(2,4,6-trimethoxybenzylthio)biphenyl-3-ol (0.948 g, 2.48 mmol) was treated with TFA:triethylsilane:DCM (8 ml:3 ml:80 ml). The solution was stirred 30 min. before 40 ml water was added and the mixture was extracted with DCM (2×80 ml). The organic was washed with water, brine, dried over magnesium sulfate and concentrated. The residue was purified by silica flash chromatography (hexane:ethyl acetate 80:20) to afford 0.335 g product (1.66 mmol, 67% yield).
후처리
- additionwas added
- extractionthe mixture was extracted with DCM (2×80 ml)
- washThe organic was washed with water, brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
- customThe residue was purified by silica flash chromatography (hexane:ethyl acetate 80:20)
출처 및 근거
- ORD 기록
- ord-5d66d310ae5a466bac3fa8881e8a5a62
- 출처 데이터셋
- uspto-grants-2009_06
- 특허 번호
- US07550505B2
반응 노트
불러오는 중…