Tetrahydrofuran → 3-(5-Amino-1,3,4-oxadiazol-2-yl)pentan-3-ol

HRID 1988199노트

반응식

HRID 1988199 반응식
[CH2:1]([Mg]Br)[CH3:2].[NH2:5][C:6]1[O:10][C:9]([C:11]([O:13]CC)=O)=[N:8][N:7]=1.[CH2:16]1COC[CH2:17]1>>[NH2:5][C:6]1[O:10][C:9]([C:11]([OH:13])([CH2:1][CH3:2])[CH2:16][CH3:17])=[N:8][N:7]=1

참가 물질

4

반응물 3

HCID 8028Tetrahydrofuran2회HCID 2756523Ethyl 5-amino-1,3,4-oxadiazole-2-carboxylateHCID 178418443HCID 178418443, 화합물

생성물 1

HCID 574378393-(5-Amino-1,3,4-oxadiazol-2-yl)pentan-3-ol

실험 절차

To a solution of ethyl magnesium bromide (200 mmol) in 300 mL of THF at 0° C. was added a suspension of ethyl 5-amino-1,3,4-oxadiazol-2-carboxylate (8.00 g, 50.9 mmol; Chemical Abstract, 1966, 64, 3558a) in THF. The reaction mixture was brought to rt and 30 min later quenched with NH4Cl. After extraction with EtOAc and drying over MgSO4, the solvent was removed. The crude product thus obtained was triturated, filtered and dried to yield the title compound.

후처리

  1. customlater quenched with NH4Cl
  2. extractionAfter extraction with EtOAc
  3. dry with materialdrying over MgSO4
  4. customthe solvent was removed
  5. customThe crude product thus obtained
  6. customwas triturated
  7. filtrationfiltered
  8. customdried

출처 및 근거

ORD 기록
ord-a93b1789eefe4102a66dfa592b1475df
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07553973B2

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