4-(4-Fluorophenyl)-2-oxo-2H-chromene-7-carbaldehyde → 7-({[5-(1-Ethyl-1-hydroxypropyl)-1,3,4-oxadiazol-2-yl]amino}methyl)-4-(4-fluorophenyl)-2H-chromen-2-one

HRID 1988201노트

반응식

HRID 1988201 반응식
[NH2:1][C:2]1[O:6][C:5]([C:7]([OH:12])([CH2:10][CH3:11])[CH2:8][CH3:9])=[N:4][N:3]=1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[C:29]3[C:24](=[CH:25][C:26]([CH:30]=O)=[CH:27][CH:28]=3)[O:23][C:22](=[O:32])[CH:21]=2)=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[CH2:8]([C:7]([C:5]1[O:6][C:2]([NH:1][CH2:30][C:26]2[CH:25]=[C:24]3[C:29]([C:20]([C:17]4[CH:18]=[CH:19][C:14]([F:13])=[CH:15][CH:16]=4)=[CH:21][C:22](=[O:32])[O:23]3)=[CH:28][CH:27]=2)=[N:3][N:4]=1)([OH:12])[CH2:10][CH3:11])[CH3:9]

참가 물질

4

반응물 2

HCID 468452294-(4-Fluorophenyl)-2-oxo-2H-chromene-7-carbaldehydeHCID 574378393-(5-Amino-1,3,4-oxadiazol-2-yl)pentan-3-ol

생성물 1

HCID 118569667-({[5-(1-Ethyl-1-hydroxypropyl)-1,3,4-oxadiazol-2-yl]amino}methyl)-4-(4-fluorophenyl)-2H-chromen-2-one

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 3-(5-amino-1,3,4-oxadiazol-2-yl)pentan-3-ol (0.446 g, 2.6 mmol) and 4-(4-fluorophenyl)-2-oxo-2H-chromene-7-carbaldehyde (0.350 g, 1.3 mmol) in 5 mL of toluene was refluxed with a Dean-Stark trap overnight. After cooling to rt the solvent was removed and the crude imine diluted in ethanol (8 ml) at 0° C. Solid NaBH4 (49 mg) was added to the solution and after 30 min of stirring aqueous NH4Cl was added to destroy the excess hydride. After dilution with EtOAc-brine, the organic phase was dried with MgSO4. Purification on silica gel with toluene-EtOAc (2:8) gave the title compound. 1H NMR (400 MHz, acetone-d6): δ 7.67 (m, 2H), 7.48 (m, 2H), 7.37 (m, 3H), 7.19 (bt, 1H), 6.33 (s, 1H), 4.66 (m, 2H), 4.31 (s, 1H), 1.85 (m, 4H), 0.85 (t, 6H).

후처리

  1. temperaturewas refluxed with a Dean-Stark trap overnight
  2. customwas removed
  3. additionthe crude imine diluted in ethanol (8 ml) at 0° C
  4. additionSolid NaBH4 (49 mg) was added to the solution and after 30 min of stirring aqueous NH4Cl
  5. additionwas added
  6. customto destroy the excess hydride
  7. dry with materialAfter dilution with EtOAc-brine, the organic phase was dried with MgSO4
  8. customPurification on silica gel with toluene-EtOAc (2:8)

출처 및 근거

ORD 기록
ord-79e7da6926b14597b1a271973d1660a7
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07553973B2

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