HCID 131727514, 화합물 → HCID 57729134, 화합물

HRID 1988245노트

반응식

HRID 1988245 반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:11]([N:13]([CH3:40])[C@H:14]([C:18]([N:20]([CH3:39])[C@H:21]([C:34]([NH:36][O:37][CH3:38])=[O:35])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([C:30]([CH3:33])([CH3:32])[CH3:31])[CH:24]=1)=[O:19])[CH:15]([CH3:17])[CH3:16])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][CH:5]=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:1][C@H:2]([C:11]([N:13]([CH3:40])[C@H:14]([C:18]([N:20]([CH3:39])[C@H:21]([C:34]([NH:36][O:37][CH3:38])=[O:35])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([C:30]([CH3:33])([CH3:31])[CH3:32])[CH:24]=1)=[O:19])[CH:15]([CH3:17])[CH3:16])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 131727514HCID 131727514, 화합물

생성물 1

HCID 57729134HCID 57729134, 화합물수율 34.2%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

To a solution of Boc-Phe(4-F)-N-Me-Val-N-Me-Tyr(3-tBu)-NHOMe (972 mg, 1.508 mmol) in methylene chloride (10 ml), TFA (7 ml) was added and stirred for 30 min. The mixture was concentrated under reduced pressure and the thus obtained residue was subjected to silica gel column chromatography (developing solvent: methylene chloride:methanol=20:1), giving the titled compound (288 mg, 34%).

후처리

  1. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1811e7c164f24367bb3c42a1be7b31ee
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07553969B1

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