Ammonia → Tyr(3-tBu)-NH2
반응식
[NH2:1][C@H:2]([C:15]([O:17]C)=O)[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:5]=1.[NH3:19]>CO>[NH2:1][C@H:2]([C:15]([NH2:19])=[O:17])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:5]=1참가 물질
4
실험 절차
To a solution of Tyr(3-tBu)-OCH3 (1.5 g, 5.97 mmol) in MeOH (10 ml), aqueous ammonia (10 ml) was added and stirred at room temperature overnight. The mixture was evaporated to remove the solvent under reduced pressure and the thus obtained residue was subjected to silica gel column chromatography (developing solvent: methylene chloride:methanol=10:1), giving Tyr(3-tBu)-NH2 (1.4 g, 99%).
후처리
- customThe mixture was evaporated
- customto remove the solvent under reduced pressure
출처 및 근거
- ORD 기록
- ord-48d41be5153f4ef6ad93e4902fccfa89
- 출처 데이터셋
- uspto-grants-2009_06
- 특허 번호
- US07553969B1
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