Citric Acid → 2-Chloro-5-(5-cyclopropyl-1H-pyrazol-3-yl)-benzoic acid

HRID 1988374노트

반응식

HRID 1988374 반응식
C([O:3][C:4](=[O:20])[C:5]1[CH:10]=[C:9]([C:11]2[CH:15]=[C:14]([CH:16]3[CH2:18][CH2:17]3)[NH:13][N:12]=2)[CH:8]=[CH:7][C:6]=1[Cl:19])C.[OH-].[K+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>CO>[Cl:19][C:6]1[CH:7]=[CH:8][C:9]([C:11]2[CH:15]=[C:14]([CH:16]3[CH2:17][CH2:18]3)[NH:13][N:12]=2)=[CH:10][C:5]=1[C:4]([OH:20])=[O:3]

참가 물질

5

반응물 3

HCID 311Citric AcidHCID 14797Potassium HydroxideHCID 588181832-chloro-5-(5-cyclopropyl-1H-pyrazol-3-yl)-benzoic acid ethyl ester

생성물 1

HCID 184386582-Chloro-5-(5-cyclopropyl-1H-pyrazol-3-yl)-benzoic acid수율 134.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-chloro-5-(5-cyclopropyl-1H-pyrazol-3-yl)-benzoic acid ethyl ester (0.05 g, 0.17 mmol) in methanol (4 mL) was added KOH (0.12 g). The mixture was shaken at room temperature for 16 h. The mixture was acidified with 10% aqueous citric acid and extracted with ethyl acetate. The combined organic layers were washed with water and brine, and concentrated in vacuo to afford the title compound (0.06 g).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe combined organic layers were washed with water and brine
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-11a6d3cd8ce34dda80cbdef098516508
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07553972B2

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