Bromine → 5-(2-Bromo-acetyl)-2-chloro-benzoic acid methyl ester

HRID 1988389노트

반응식

HRID 1988389 반응식
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:6][C:5]=1[Cl:13].[Br:15]Br>C(O)(=O)C.Br.C(O)(=O)C>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([C:10](=[O:12])[CH2:11][Br:15])[CH:7]=[CH:6][C:5]=1[Cl:13]

참가 물질

5

반응물 2

HCID 24408BromineHCID 58818179Methyl 5-acetyl-2-chlorobenzoate

생성물 1

HCID 588181855-(2-Bromo-acetyl)-2-chloro-benzoic acid methyl ester수율 102.2%

시약·촉매·용매 2

HCID 21893785Acetic Acid Mixture with Hydrobromic Acid촉매HCID 176Acetic Acid용매

실험 절차

To a solution of 5-acetyl-2-chloro-benzoic acid methyl ester (100 mg, 0.47 mmol) in glacial acetic acid (5 mL) was added bromine (0.05 mL, 0.94 mmol). The mixture was stirred at room temperature for 2 h. Hydrobromic acid-acetic acid (2 drops, 30%) was added and the mixture was stirred for 10 minutes. The mixture was concentrated in vacuo to afford the title compound (140 mg).

후처리

  1. stirringthe mixture was stirred for 10 minutes
  2. concentrationThe mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-8924183b1f654745bf1ae6750523d990
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07553972B2

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