Thioacetamide → 2-Chloro-5-(2-methyl-thiazol-4-yl)-benzoic acid methyl ester
반응식
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([C:10](=O)[CH2:11]Br)[CH:7]=[CH:6][C:5]=1[Cl:14].[C:16]([NH2:19])(=[S:18])[CH3:17]>C(O)C>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([C:10]2[N:19]=[C:16]([CH3:17])[S:18][CH:11]=2)[CH:7]=[CH:6][C:5]=1[Cl:14]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
A mixture of 5-(2-bromo-acetyl)-2-chloro-benzoic acid methyl ester (25 mg, 0.09 mmol) and thioacetamide (6.5 mg, 0.08 mmol) in ethanol (2 mL) and stirred at 50° C. for 15 minutes. The mixture was cooled to room temperature and concentrated in vacuo. The residue was dissolved in ethyl acetate, washed with water, and brine, dried over sodium sulfate, filtered and concentrated in vacuo to afford the title compound (10 mg).
후처리
- temperatureThe mixture was cooled to room temperature
- concentrationconcentrated in vacuo
- dissolutionThe residue was dissolved in ethyl acetate
- washwashed with water, and brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-6d8bc77bbe0e40ecadc94596b44d9cec
- 출처 데이터셋
- uspto-grants-2009_06
- 특허 번호
- US07553972B2
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