3,5-Difluorobenzyl alcohol → 4-[(3,5-Difluorophenyl)methoxy]-3-nitropyridine

HRID 1988847노트

반응식

HRID 1988847 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([F:20])[CH:19]=1)[CH2:15][OH:16]>>[F:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:18]([F:20])[CH:19]=1)[CH2:15][O:16][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9]

참가 물질

3

반응물 2

HCID 5227213,5-Difluorobenzyl alcoholHCID 27357814-Chloro-3-nitropyridine

생성물 1

HCID 687048604-[(3,5-Difluorophenyl)methoxy]-3-nitropyridine수율 78%

실험 절차

In accordance with the same procedures as in Preparation 2, except for using 4-chloro-3-nitropyridine prepared in Step 1 of Preparation 1 and 3,5-difluorobenzyl alcohol, the titled compound was obtained as a yellow solid. (Yield: 78.0%)

후처리

  1. customIn accordance with the same procedures as in Preparation 2

출처 및 근거

ORD 기록
ord-69c17bbef72140f6ad636df971a3b42f
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07642269B2

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