1,1'-Carbonyldiimidazole → 6-bromo-1,2-benzisoxazol-3-ol
반응식
C(N1C=CN=C1)(N1C=CN=C1)=O.[Br:13][C:14]1[CH:23]=[CH:22][C:17]([C:18]([NH:20]O)=[O:19])=[C:16]([OH:24])[CH:15]=1>O1CCCC1>[Br:13][C:14]1[CH:23]=[CH:22][C:17]2[C:18](=[O:19])[NH:20][O:24][C:16]=2[CH:15]=1참가 물질
4
실험 절차
A solution of carbonyldiimidazole (0.75 g) in dry tetrahydrofuran (15 ml) was added to a refluxing solution of 4-bromo-N,2-dihydroxybenzamide (Intermediate 23) (0.56 g) in dry tetrahydrofuran (10 ml) then stirred for 2 h. The solvent was removed under vacuum, the residue was suspended in water and 2N hydrochloric acid (10 ml) was added. The resulting precipitate was collected by filtration, washed with water then cyclohexane and dried to give the title compound as a cream solid (0.37 g).
후처리
- customThe solvent was removed under vacuum
- addition2N hydrochloric acid (10 ml) was added
- filtrationThe resulting precipitate was collected by filtration
- washwashed with water
- dry with materialcyclohexane and dried
출처 및 근거
- ORD 기록
- ord-1975a99a796442f0bc7b5298016be985
- 출처 데이터셋
- uspto-grants-2010_01
- 특허 번호
- US07642276B2
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