Ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate → 7-Bromo-4-hydroxycoumarin

HRID 1988889노트

반응식

HRID 1988889 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:15])[CH2:9][C:10]([O:12]CC)=O)=[C:4]([OH:16])[CH:3]=1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([C:8]([OH:15])=[CH:9][C:10](=[O:12])[O:16]2)=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 59127384Ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate2회

생성물 1

HCID 546962297-Bromo-4-hydroxycoumarin수율 78.6%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate (Intermediate 30) (2.0 g) in dry toluene (20 ml) was stirred at reflux under nitrogen for 24 h. On cooling the resulting precipitate was collected by filtration, washed with ether and dried to give the title compound as a white solid (1.32 g).

후처리

  1. temperatureat reflux under nitrogen for 24 h
  2. temperatureOn cooling the resulting precipitate
  3. filtrationwas collected by filtration
  4. washwashed with ether
  5. customdried

출처 및 근거

ORD 기록
ord-ca540a040e4345979095e68bbca15e30
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07642276B2

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