1,8-Diazabicyclo(5.4.0)undec-7-ene → 6-bromo-N-cyclopropyl-1,2-benzisoxazol-3-amine
반응식
N12CCCN=C1CCCCC2.[Br:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[N:24][OH:25])[NH:20][CH:21]2[CH2:23][CH2:22]2)=[C:15](F)[CH:14]=1>O1CCCC1>[Br:12][C:13]1[CH:18]=[CH:17][C:16]2[C:19]([NH:20][CH:21]3[CH2:23][CH2:22]3)=[N:24][O:25][C:15]=2[CH:14]=1참가 물질
4
실험 절차
1,8-Diazabicyclo[5.4.0]undec-7-ene (0.12 ml) was added to 4-bromo-N-cyclopropyl-2-fluoro-N′-hydroxybenzenecarboximidamide (Intermediate 52) (0.2 g) in tetrahydrofuran (2 ml) then heated at 150° in a microwave for 70 min. The mixture was applied to a Varian Bond-Elut SPE cartridge (silica, 20 g) then eluted with cyclohexane:ethyl acetate (100:0 to 80:20) to give the title compound as a white solid (0.13 g).
후처리
- temperaturethen heated at 150° in a microwave for 70 min
- washthen eluted with cyclohexane:ethyl acetate (100:0 to 80:20)
출처 및 근거
- ORD 기록
- ord-c25a435f6b26479aac368fa367a32617
- 출처 데이터셋
- uspto-grants-2010_01
- 특허 번호
- US07642276B2
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