2-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine → 2-(4-Bromo-imidazol-1-yl)-4-(3,4-dichlorophenyl)-6-trifluoromethyl-pyrimidine

HRID 1989174노트

반응식

HRID 1989174 반응식
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[N:3]=1.[Br:20][C:21]1[N:22]=[CH:23][NH:24][CH:25]=1>>[Br:20][C:21]1[N:22]=[CH:23][N:24]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=3)[CH:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[N:3]=2)[CH:25]=1

참가 물질

3

반응물 2

HCID 154777402-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidineHCID 178418934HCID 178418934, 화합물

생성물 1

HCID 574687572-(4-Bromo-imidazol-1-yl)-4-(3,4-dichlorophenyl)-6-trifluoromethyl-pyrimidine

실험 절차

The title compound was prepared from 2-chloro-4-(3,4-dichloro-phenyl)-6-trifluoromethyl-pyrimidine (example A.7) (0.50 g, 1.53 mmol) and commercially available 4-bromo-imidazole (0.34 g, 2.31 mmol) according to the general procedure IVb. Obtained as a white solid (0.38 g, 57%). MS (ISP) 439.0 [(M+H)+]; mp 225.5° C.

출처 및 근거

ORD 기록
ord-85fec71f8f084a5aad68541e7f749300
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07642264B2

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